Chelsea could become the first team to eliminate Manchester United in five consecutive FA Cup meetings.
They meet in the FA Cup for the fifth time in six years, including replays. Chelsea won 1-0 on the last three occasions, following a 2-2 draw at Old Trafford in 2013.
The Red Devils have won just two of their last 22 away games against Chelsea, failing to win any of their last nine.
This will be the 64th time in less than 22 years that these two clubs have met, making it the most-played fixture between English sides since the start of the 1997-98 season.
The defending champions are seeking to reach the FA Cup quarter-finals for the fourth consecutive season. They’ve reached the past two finals.
Chelsea have progressed from their last 10 FA Cup home games, including a shootout win against Norwich.
The Blues could keep five clean sheets in a row for the first time in the FA Cup.
They have lost six of their last 14 league matches, having gone unbeaten in the first 12 this season.
The Red Devils have eliminated the FA Cup holders on an unrivalled 10 occasions. They last did so in 2011-12 against Manchester City.
United, vying to equal Arsenal’s record of 13 FA Cup titles, are looking to reach the quarter-finals for the fifth consecutive season. They last achieved that feat in 1966.
They have scored in their first 18 away games of a season in all competitions for the first time.
Former Chelsea forward Romelu Lukaku has scored 13 goals in his last 15 FA Cup appearances.